Abstract
Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cells, Cultured
-
Cyclopentanes / chemistry*
-
Cyclopentanes / pharmacology*
-
Drug Evaluation, Preclinical
-
Humans
-
Molecular Structure
-
Rats
-
Receptors, Glutamate / drug effects
-
Receptors, Glutamate / metabolism*
-
Receptors, Serotonin / drug effects
-
Receptors, Serotonin / metabolism*
-
Serotonin Receptor Agonists / chemistry*
-
Serotonin Receptor Agonists / metabolism
-
Serotonin Receptor Agonists / pharmacology
-
Stereoisomerism*
-
Tricarboxylic Acids / chemistry*
-
Tricarboxylic Acids / pharmacology*
Substances
-
1-aminocyclopentane-1,2,4-tricarboxylic acid
-
Cyclopentanes
-
Receptors, Glutamate
-
Receptors, Serotonin
-
Serotonin Receptor Agonists
-
Tricarboxylic Acids